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Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
Ring C, Ginsberg MH, Haling J, Pendergast AM. Ring C, et al. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):149-54. doi: 10.1073/pnas.1012316108. Epub 2010 Dec 20. Proc Natl Acad Sci U S A. 2011. PMID: 21173240 Free PMC article.
Mice lacking Abi1 or alpha4 exhibit midgestational lethality with abnormalities in placental and cardiovascular development. ...Moreover, Abi1-deficient cells expressing alpha4 have impaired cell spreading, which is rescued by WT Abi1 but not an Abi …
Mice lacking Abi1 or alpha4 exhibit midgestational lethality with abnormalities in placental and cardiovascular development. . …
Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.
Li Y, Clough N, Sun X, Yu W, Abbott BL, Hogan CJ, Dai Z. Li Y, et al. J Cell Sci. 2007 Apr 15;120(Pt 8):1436-46. doi: 10.1242/jcs.03430. Epub 2007 Mar 27. J Cell Sci. 2007. PMID: 17389688 Free PMC article.
Hematopoietic cells isolated from patients with Bcr-Abl-positive leukemia exhibit multiple abnormalities of cytoskeletal and integrin function. These abnormalities are thought to play a role in the pathogenesis of leukemia; however, the molecular events leadi …
Hematopoietic cells isolated from patients with Bcr-Abl-positive leukemia exhibit multiple abnormalities of cytoskeletal and i …